Early Thymocyte Development Is Regulated by Modulation of E2a Protein Activity

The E2A gene encodes the E47 and E12 basic helix-loop-helix (bHLH) transcription factors. T cell development in E2A-deficient mice is partially arrested before lineage commitment. Here we demonstrate that E47 expression becomes uniformly high at the point at which thymocytes begin to commit towards...

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Detalles Bibliográficos
Autores principales: Engel, Isaac, Johns, Carol, Bain, Gretchen, Rivera, Richard R., Murre, Cornelis
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2001
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2195962/
https://www.ncbi.nlm.nih.gov/pubmed/11560990

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2195962/
https://www.ncbi.nlm.nih.gov/pubmed/11560990

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