Apical Membrane Localization of the Adenomatous Polyposis Coli Tumor Suppressor Protein and Subcellular Distribution of the β-Catenin Destruction Complex in Polarized Epithelial Cells

The adenomatous polyposis coli (APC) protein is implicated in the majority of hereditary and sporadic colon cancers. APC is known to function as a tumor suppressor through downregulation of β-catenin as part of a high molecular weight complex known as the β-catenin destruction complex. The molecular...

Descripción completa

Detalles Bibliográficos
Autores principales: Reinacher-Schick, Anke, Gumbiner, Barry M.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2001
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2196003/
https://www.ncbi.nlm.nih.gov/pubmed/11157977

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2196003/
https://www.ncbi.nlm.nih.gov/pubmed/11157977

Ejemplares similares