Sustained Activation of Lyn Tyrosine Kinase In Vivo Leads to Autoimmunity

Genetic ablation of the Lyn tyrosine kinase has revealed unique inhibitory roles in B lymphocyte signaling. We now report the consequences of sustained activation of Lyn in vivo using a targeted gain-of-function mutation (Lyn(up/up) mice). Lyn(up/up) mice have reduced numbers of conventional B lymph...

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Detalles Bibliográficos
Autores principales: Hibbs, Margaret L., Harder, Kenneth W., Armes, Jane, Kountouri, Nicole, Quilici, Cathy, Casagranda, Franca, Dunn, Ashley R., Tarlinton, David M.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2002
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2196073/
https://www.ncbi.nlm.nih.gov/pubmed/12486102
http://dx.doi.org/10.1084/jem.20020515

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2196073/
https://www.ncbi.nlm.nih.gov/pubmed/12486102
http://dx.doi.org/10.1084/jem.20020515

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