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Allelic Variation of MHC Structure Alters Peptide Ligands to Induce Atypical Partial Agonistic CD8(+) T Cell Function

T cell receptors recognize small changes in peptide ligands leading to different T cell responses. Here, we analyzed a panel of HLA-A2–Tax11-19 reactive T cell clones to examine how small allelic variations of MHC molecules could alter the functional outcome of antigen recognition. Similar to the ef...

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Detalles Bibliográficos
Autores principales: Lim, Dong-Gyun, Slavik, Jacqueline M., Bourcier, Katarzyna, Smith, Kathrine J., Hafler, David A.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2003
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2196091/
https://www.ncbi.nlm.nih.gov/pubmed/12847139
http://dx.doi.org/10.1084/jem.20021796