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Allelic Variation of MHC Structure Alters Peptide Ligands to Induce Atypical Partial Agonistic CD8(+) T Cell Function
T cell receptors recognize small changes in peptide ligands leading to different T cell responses. Here, we analyzed a panel of HLA-A2–Tax11-19 reactive T cell clones to examine how small allelic variations of MHC molecules could alter the functional outcome of antigen recognition. Similar to the ef...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2003
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2196091/ https://www.ncbi.nlm.nih.gov/pubmed/12847139 http://dx.doi.org/10.1084/jem.20021796 |