Downregulation of CD1 Marks Acquisition of Functional Maturation of Human Thymocytes and Defines a Control Point in Late Stages of Human T Cell Development

We have investigated whether in the human thymus transition of CD4(+)CD8(+) double positive (DP) to CD4(+) or CD8(+) single positive (SP) cells is sufficient for generation of functional immunocompetent T cells. Using the capacity of thymocytes to expand in vitro in response to PHA and IL-2 as a cri...

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Detalles Bibliográficos
Autores principales: Res, Pieter, Blom, Bianca, Hori, Toshiyuki, Weijer, Kees, Spits, Hergen
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1997
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2196108/
https://www.ncbi.nlm.nih.gov/pubmed/8996250

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2196108/
https://www.ncbi.nlm.nih.gov/pubmed/8996250

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