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The Single Positive T Cells Found in CD3-ζ/η(−) (/−) Mice Overtly React with Self–Major Histocompatibility Complex Molecules upon Restoration of Normal Surface Density of T Cell Receptor–CD3 Complex
CD3-ζ/η–deficient mice have small thymuses containing cells that show a profound reduction in the surface levels of T cell receptors and terminate their differentiation at the CD4(+)CD8(+) stage. Rather unexpectedly, CD3(−) (or) (very) (low) single positive T cells accumulate over time in the spleen...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
1997
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2196153/ https://www.ncbi.nlm.nih.gov/pubmed/9034149 |