Cargando…

Signaling from β(1)- and β(2)-adrenergic receptors is defined by differential interactions with PDE4

β(1)- and β(2)-adrenergic receptors (βARs) are highly homologous, yet they play clearly distinct roles in cardiac physiology and pathology. Myocyte contraction, for instance, is readily stimulated by β(1)AR but not β(2)AR signaling, and chronic stimulation of the two receptors has opposing effects o...

Descripción completa

Detalles Bibliográficos
Autores principales:	Richter, Wito, Day, Peter, Agrawal, Rani, Bruss, Matthew D, Granier, Sébastien, Wang, Yvonne L, Rasmussen, Søren G F, Horner, Kathleen, Wang, Ping, Lei, Tao, Patterson, Andrew J, Kobilka, Brian, Conti, Marco
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2008
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2196435/ https://www.ncbi.nlm.nih.gov/pubmed/18188154 http://dx.doi.org/10.1038/sj.emboj.7601968

Ejemplares similares

Phosphodiesterase 4D disruption causes β2 adrenergic receptors to behave like β1 adrenergic receptors in vivo
por: Pearl, N, et al.
Publicado: (2006)

Roles of GRK and PDE4 Activities in the Regulation of β(2) Adrenergic Signaling
por: Xin, Wenkuan, et al.
Publicado: (2008)

PDE4D and PDE4B Function in Distinct Subcellular Compartments in Mouse Embryonic Fibroblasts
por: Blackman, Brigitte E., et al.
Publicado: (2011)

Conserved expression and functions of PDE4 in rodent and human heart
por: Richter, Wito, et al.
Publicado: (2010)

Crystal Structure of the β(2)Adrenergic Receptor-Gs protein complex
por: Rasmussen, Søren G.F., et al.
Publicado: (2011)

Local membrane charge regulates β(2) adrenergic receptor coupling to G(i3)
por: Strohman, M. J., et al.
Publicado: (2019)

Assessment of PDE4 Inhibitor-Induced Hypothermia as a Correlate of Nausea in Mice
por: Boyd, Abigail, et al.
Publicado: (2021)

Acute PDE4 Inhibition Induces a Transient Increase in Blood Glucose in Mice
por: Irelan, Daniel, et al.
Publicado: (2023)

Non-Selective PDE4 Inhibition Induces a Rapid and Transient Decrease of Serum Potassium in Mice
por: Boyd, Abigail, et al.
Publicado: (2022)

Phosphodiesterase 10A (PDE10A) as a novel target to suppress β-catenin and RAS signaling in epithelial ovarian cancer
por: Borneman, Rebecca M., et al.
Publicado: (2022)

G(s) protein peptidomimetics as allosteric modulators of the β(2)-adrenergic receptor
por: Boyhus, Lotte-Emilie, et al.
Publicado: (2018)

Function and dynamics of the intrinsically disordered carboxyl terminus of β2 adrenergic receptor
por: Heng, Jie, et al.
Publicado: (2023)

β‐Adrenergic signaling in skin cancer
por: Batalla‐Covello, Jennifer, et al.
Publicado: (2022)

Gi-protein-coupled β (1)-adrenergic receptor: re-understanding the selectivity of β (1)-adrenergic receptor to G protein : Gi-protein-coupled β (1)-adrenergic receptor
por: Chen, Hao, et al.
Publicado: (2022)

Cyclic AMP compartments and signaling specificity: Role of cyclic nucleotide phosphodiesterases
por: Conti, Marco, et al.
Publicado: (2014)

β-adrenergic modulation of oddball responses in humans
por: Strange, Bryan A, et al.
Publicado: (2007)

Internalization Dissociates β(2)-Adrenergic Receptors
por: Lan, Tien-Hung, et al.
Publicado: (2011)

β-Adrenergic Receptor Signaling in Prostate Cancer
por: Braadland, Peder Rustøen, et al.
Publicado: (2015)

Optodynamic simulation of β-adrenergic receptor signalling
por: Siuda, Edward R., et al.
Publicado: (2015)

β-Adrenergic Receptor and Insulin Resistance in the Heart
por: Mangmool, Supachoke, et al.
Publicado: (2017)

Role of β-adrenergic signaling in masseter muscle
por: Ito, Aiko, et al.
Publicado: (2019)

Muscle Plasticity and β(2)-Adrenergic Receptors: Adaptive Responses of β(2)-Adrenergic Receptor Expression to Muscle Hypertrophy and Atrophy
por: Sato, Shogo, et al.
Publicado: (2011)

Baicalein Ameliorates Aβ-Induced Memory Deficits and Neuronal Atrophy via Inhibition of PDE2 and PDE4
por: Shi, Jing, et al.
Publicado: (2021)

Bidirectional Role of β2-Adrenergic Receptor in Autoimmune Diseases
por: Wu, Li, et al.
Publicado: (2018)

Targeting β(3)-Adrenergic Receptors in the Heart: Selective Agonism and β-Blockade
por: Cannavo, Alessandro, et al.
Publicado: (2017)

The effect of antecedent hypoglycaemia on β(2)-adrenergic sensitivity in healthy participants with the Arg16Gly polymorphism of the β(2)-adrenergic receptor
por: Schouwenberg, B. J. J. W., et al.
Publicado: (2011)

Cardiac physiologic regulation of sub-type specific adrenergic receptors in transgenic mice overexpressing β(1)- and β(2)-adrenergic receptors
por: Kim, Ka Eul, et al.
Publicado: (2016)

Characterization of β-adrenergic receptors in bovine intramuscular and subcutaneous adipose tissue: comparison of lubabegron fumarate with β-adrenergic receptor agonists and antagonists
por: Hwang, Jinhee H, et al.
Publicado: (2021)

Differential β(2)-adrenergic receptor expression defines the phenotype of non-tumorigenic and malignant human breast cell lines
por: Gargiulo, Lucía, et al.
Publicado: (2014)

Molecular Basis of Ligand Dissociation in β-Adrenergic Receptors
por: González, Angel, et al.
Publicado: (2011)

Agonist-Directed Desensitization of the β(2)-Adrenergic Receptor
por: Goral, Vasiliy, et al.
Publicado: (2011)

Bench-to-bedside review: β-Adrenergic modulation in sepsis
por: de Montmollin, Etienne, et al.
Publicado: (2009)

Correction: Role of β-adrenergic signaling in masseter muscle
Publicado: (2019)

β-adrenergic signaling broadly contributes to LTP induction
por: Jȩdrzejewska-Szmek, Joanna, et al.
Publicado: (2017)

Glucocorticoid and β‐adrenergic regulation of hippocampal dendritic spines
por: Lesuis, Sylvie L., et al.
Publicado: (2019)

β-agonists for ARDS: the dark side of adrenergic stimulation?
por: Thompson, B Taylor
Publicado: (2012)

β-Adrenergic Receptor-Stimulated Cardiac Myocyte Apoptosis: Role of β1 Integrins
por: Amin, Parthiv, et al.
Publicado: (2011)

Enriched environment enhances β‐adrenergic signaling to prevent microglia inflammation by amyloid‐β
por: Xu, Huixin, et al.
Publicado: (2018)

β-Adrenergic receptor signaling in cardiac function and heart failure
por: Madamanchi, Aasakiran
Publicado: (2007)

Does atenolol differ from other β-adrenergic blockers?
por: Aursnes, Ivar, et al.
Publicado: (2007)

Cannot write session to /tmp/vufind_sessions/sess_7vaq5rntih2d9gbo8e2cepjrb6