Elevating the level of Cdc34/Ubc3 ubiquitin-conjugating enzyme in mitosis inhibits association of CENP-E with kinetochores and blocks the metaphase alignment of chromosomes

Cdc34/Ubc3 is a ubiquitin-conjugating enzyme that functions in targeting proteins for proteasome-mediated degradation at the G1 to S cell cycle transition. Elevation of Cdc34 protein levels by microinjection of bacterially expressed Cdc34 into mammalian cells at prophase inhibited chromosome congres...

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Detalles Bibliográficos
Autores principales: Topper, Leana M., Bastians, Holger, Ruderman, Joan V., Gorbsky, Gary J.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2001
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2196447/
https://www.ncbi.nlm.nih.gov/pubmed/11514588
http://dx.doi.org/10.1083/jcb.200104130

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2196447/
https://www.ncbi.nlm.nih.gov/pubmed/11514588
http://dx.doi.org/10.1083/jcb.200104130

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