Rapid nitric oxide–induced desensitization of the cGMP response is caused by increased activity of phosphodiesterase type 5 paralleled by phosphorylation of the enzyme

Most of the effects of the signaling molecule nitric oxide (NO) are mediated by cGMP, which is synthesized by soluble guanylyl cyclase and degraded by phosphodiesterases. Here we show that in platelets and aortic tissue, NO led to a biphasic response characterized by a tremendous increase in cGMP (u...

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Detalles Bibliográficos
Autores principales: Mullershausen, Florian, Russwurm, Michael, Thompson, W. Joseph, Liu, Li, Koesling, Doris, Friebe, Andreas
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2001
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2198829/
https://www.ncbi.nlm.nih.gov/pubmed/11604422
http://dx.doi.org/10.1083/jcb.200107001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2198829/
https://www.ncbi.nlm.nih.gov/pubmed/11604422
http://dx.doi.org/10.1083/jcb.200107001

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