Commitment of Immature CD4(+)8(+) Thymocytes to the CD4 Lineage Requires CD3 Signaling but Does Not Require Expression of Clonotypic T Cell Receptor (TCR) Chains

As a consequence of positive selection in the thymus, immature CD4(+)8(+) double-positive, [DP] thymocytes selectively terminate synthesis of one coreceptor molecule and, as a result, differentiate into either CD4(+) or CD8(+) T cells. The decision by individual DP thymocytes to terminate synthesis...

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Detalles Bibliográficos
Autores principales: Suzuki, Harumi, Shinkai, Yoichi, Granger, Lawrence G., Alt, Frederick W., Love, Paul E., Singer, Alfred
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1997
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2198962/
https://www.ncbi.nlm.nih.gov/pubmed/9206993

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2198962/
https://www.ncbi.nlm.nih.gov/pubmed/9206993

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