Interaction of Chemokine Receptor CCR5 with its Ligands: Multiple Domains for HIV-1 gp120 Binding and a Single Domain for Chemokine Binding

CCR5 is a chemokine receptor expressed by T cells and macrophages, which also functions as the principal coreceptor for macrophage (M)-tropic strains of HIV-1. To understand the molecular basis of the binding of chemokines and HIV-1 to CCR5, we developed a number of mAbs that inhibit the various int...

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Detalles Bibliográficos
Autores principales: Wu, Lijun, LaRosa, Greg, Kassam, Nasim, Gordon, Cynthia J., Heath, Heidi, Ruffing, Nancy, Chen, Howard, Humblias, Jason, Samson, Michel, Parmentier, Marc, Moore, John P., Mackay, Charles R.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1997
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2199098/
https://www.ncbi.nlm.nih.gov/pubmed/9334377

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2199098/
https://www.ncbi.nlm.nih.gov/pubmed/9334377

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