Enforced Bcl-2 Expression Inhibits Antigen-mediated Clonal Elimination of Peripheral B Cells in an Antigen Dose–dependent Manner and Promotes Receptor Editing in Autoreactive, Immature B Cells

The mechanisms that establish immune tolerance in immature and mature B cells appear to be distinct. Membrane-bound autoantigen is thought to induce developmental arrest and receptor editing in immature B cells, whereas mature B cells have shortened lifespans when exposed to the same stimulus. In th...

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Detalles Bibliográficos
Autores principales: Lang, Julie, Arnold, B., Hammerling, G., Harris, Alan W., Korsmeyer, Stanley, Russell, David, Strasser, Andreas, Nemazee, David
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1997
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2199120/
https://www.ncbi.nlm.nih.gov/pubmed/9348309

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2199120/
https://www.ncbi.nlm.nih.gov/pubmed/9348309

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