Somatic Hypermutation Introduces Insertions and Deletions into Immunoglobulin V Genes

During a germinal center reaction, random mutations are introduced into immunoglobulin V genes to increase the affinity of antibody molecules and to further diversify the B cell repertoire. Antigen-directed selection of B cell clones that generate high affinity surface Ig results in the affinity mat...

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Detalles Bibliográficos
Autores principales: Wilson, Patrick C., de Bouteiller, Odette, Liu, Yong-Jun, Potter, Kathleen, Banchereau, Jacques, Capra, J. Donald, Pascual, Virginia
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1998
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2199186/
https://www.ncbi.nlm.nih.gov/pubmed/9419211

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2199186/
https://www.ncbi.nlm.nih.gov/pubmed/9419211

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