Coordinate interactions of Csk, Src, and Syk kinases with αIIbβ3 initiate integrin signaling to the cytoskeleton

Integrins regulate cell adhesion and motility through tyrosine kinases, but initiation of this process is poorly understood. We find here that Src associates constitutively with integrin αIIbβ3 in platelets. Platelet adhesion to fibrinogen caused a rapid increase in αIIbβ3-associated Src activity, a...

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Detalles Bibliográficos
Autores principales: Obergfell, Achim, Eto, Koji, Mocsai, Attila, Buensuceso, Charito, Moores, Sheri L., Brugge, Joan S., Lowell, Clifford A., Shattil, Sanford J.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2002
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2199242/
https://www.ncbi.nlm.nih.gov/pubmed/11940607
http://dx.doi.org/10.1083/jcb.200112113

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2199242/
https://www.ncbi.nlm.nih.gov/pubmed/11940607
http://dx.doi.org/10.1083/jcb.200112113

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