Specific SHP-2 partitioning in raft domains triggers integrin-mediated signaling via Rho activation

Cell signaling does not occur randomly over the cell surface, but is integrated within cholesterol-enriched membrane domains, termed rafts. By targeting SHP-2 to raft domains or to a non-raft plasma membrane fraction, we studied the functional role of rafts in signaling. Serum-depleted, nonattached...

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Detalles Bibliográficos
Autores principales: Lacalle, Rosa Ana, Mira, Emilia, Gómez-Moutón, Concepción, Jiménez-Baranda, Sonia, Martínez-A., Carlos, Mañes, Santos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2002
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2199243/
https://www.ncbi.nlm.nih.gov/pubmed/11956229
http://dx.doi.org/10.1083/jcb.200109031

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2199243/
https://www.ncbi.nlm.nih.gov/pubmed/11956229
http://dx.doi.org/10.1083/jcb.200109031

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