A novel class of herpesvirus-encoded membrane-bound E3 ubiquitin ligases regulates endocytosis of proteins involved in immune recognition

Kaposi's sarcoma-associated herpesvirus encodes two transmembrane proteins (modulator of immune recognition [MIR]1 and MIR2) that downregulate cell surface molecules (MHC-I, B7.2, and ICAM-1) involved in the immune recognition of infected cells. This downregulation results from enhanced endocyt...

Descripción completa

Detalles Bibliográficos
Autores principales: Coscoy, Laurent, Sanchez, David Jesse, Ganem, Don
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2001
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2199318/
https://www.ncbi.nlm.nih.gov/pubmed/11756476
http://dx.doi.org/10.1083/jcb.200111010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2199318/
https://www.ncbi.nlm.nih.gov/pubmed/11756476
http://dx.doi.org/10.1083/jcb.200111010

Ejemplares similares