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Different cofactor activities in γ-secretase assembly: evidence for a nicastrin–Aph-1 subcomplex
The γ-secretase complex is required for intramembrane cleavage of several integral membrane proteins, including the Notch receptor, where it generates an active signaling fragment. Four putative γ-secretase components have been identified—presenilin (Psn), nicastrin (Nct), Aph-1, and Pen-2. Here, we...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2003
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2199374/ https://www.ncbi.nlm.nih.gov/pubmed/12771124 http://dx.doi.org/10.1083/jcb.200304014 |