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Isoprenylation is required for the processing of the lamin A precursor
The nuclear lamina proteins, prelamin A, lamin B, and a 70-kD lamina- associated protein, are posttranslationally modified by a metabolite derived from mevalonate. This modification can be inhibited by treatment with (3-R,S)-3-fluoromevalonate, demonstrating that it is isoprenoid in nature. We have...
| Formato: | Texto |
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| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
1990
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2200179/ https://www.ncbi.nlm.nih.gov/pubmed/2335559 |