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Synthesis of the Benzo-fused Indolizidine Alkaloid Mimics

A general synthesis of various benzo-fused indolizidine alkaloid mimics has been developed. The indolizidine derivatives 8 were prepared via heteroaryl Grignard addition to N-acylpyridinium salts followed by an intramolecular Heck cyclization. Further substitution reactions were developed to demonst...

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Detalles Bibliográficos
Autores principales: Comins, Daniel L, Higuchi, Kazuhiro
Formato: Texto
Lenguaje:English
Publicado: Beilstein-Institut 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2200666/
https://www.ncbi.nlm.nih.gov/pubmed/18047680
http://dx.doi.org/10.1186/1860-5397-3-42