Synthesis of the Benzo-fused Indolizidine Alkaloid Mimics

A general synthesis of various benzo-fused indolizidine alkaloid mimics has been developed. The indolizidine derivatives 8 were prepared via heteroaryl Grignard addition to N-acylpyridinium salts followed by an intramolecular Heck cyclization. Further substitution reactions were developed to demonst...

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Detalles Bibliográficos
Autores principales: Comins, Daniel L, Higuchi, Kazuhiro
Formato: Texto
Lenguaje:English
Publicado: Beilstein-Institut 2007
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2200666/
https://www.ncbi.nlm.nih.gov/pubmed/18047680
http://dx.doi.org/10.1186/1860-5397-3-42
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author Comins, Daniel L
Higuchi, Kazuhiro
author_facet Comins, Daniel L
Higuchi, Kazuhiro
author_sort Comins, Daniel L
collection PubMed
description A general synthesis of various benzo-fused indolizidine alkaloid mimics has been developed. The indolizidine derivatives 8 were prepared via heteroaryl Grignard addition to N-acylpyridinium salts followed by an intramolecular Heck cyclization. Further substitution reactions were developed to demonstrate that heterocycles 8 are good scaffolds for chemical library preparation.
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spelling pubmed-22006662008-01-16 Synthesis of the Benzo-fused Indolizidine Alkaloid Mimics Comins, Daniel L Higuchi, Kazuhiro Beilstein J Org Chem Full Research Paper A general synthesis of various benzo-fused indolizidine alkaloid mimics has been developed. The indolizidine derivatives 8 were prepared via heteroaryl Grignard addition to N-acylpyridinium salts followed by an intramolecular Heck cyclization. Further substitution reactions were developed to demonstrate that heterocycles 8 are good scaffolds for chemical library preparation. Beilstein-Institut 2007-11-30 /pmc/articles/PMC2200666/ /pubmed/18047680 http://dx.doi.org/10.1186/1860-5397-3-42 Text en Copyright © 2007, Comins and Higuchi; licencee Beilstein-Institut https://creativecommons.org/licenses/by/2.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Full Research Paper
Comins, Daniel L
Higuchi, Kazuhiro
Synthesis of the Benzo-fused Indolizidine Alkaloid Mimics
title Synthesis of the Benzo-fused Indolizidine Alkaloid Mimics
title_full Synthesis of the Benzo-fused Indolizidine Alkaloid Mimics
title_fullStr Synthesis of the Benzo-fused Indolizidine Alkaloid Mimics
title_full_unstemmed Synthesis of the Benzo-fused Indolizidine Alkaloid Mimics
title_short Synthesis of the Benzo-fused Indolizidine Alkaloid Mimics
title_sort synthesis of the benzo-fused indolizidine alkaloid mimics
topic Full Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2200666/
https://www.ncbi.nlm.nih.gov/pubmed/18047680
http://dx.doi.org/10.1186/1860-5397-3-42
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