Polyglutamine Expansion Accelerates the Dynamics of Ataxin-1 and Does Not Result in Aggregate Formation

BACKGROUND: Polyglutamine expansion disorders are caused by an expansion of the polyglutamine (polyQ) tract in the disease related protein, leading to severe neurodegeneration. All polyQ disorders are hallmarked by the presence of intracellular aggregates containing the expanded protein in affected...

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Detalles Bibliográficos
Autores principales: Krol, Hilde A., Krawczyk, Przemek M., Bosch, Klazien S., Aten, Jacob A., Hol, Elly M., Reits, Eric A.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2200796/
https://www.ncbi.nlm.nih.gov/pubmed/18231590
http://dx.doi.org/10.1371/journal.pone.0001503

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2200796/
https://www.ncbi.nlm.nih.gov/pubmed/18231590
http://dx.doi.org/10.1371/journal.pone.0001503

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