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Biological variability dominates and influences analytical variance in HPLC-ECD studies of the human plasma metabolome

BACKGROUND: Biomarker-based assessments of biological samples are widespread in clinical, pre-clinical, and epidemiological investigations. We previously developed serum metabolomic profiles assessed by HPLC-separations coupled with coulometric array detection that can accurately identify ad libitum...

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Detalles Bibliográficos
Autores principales: Shurubor, Yevgeniya I, Matson, Wayne R, Willett, Walter C, Hankinson, Susan E, Kristal, Bruce S
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2203971/
https://www.ncbi.nlm.nih.gov/pubmed/17997839
http://dx.doi.org/10.1186/1472-6890-7-9