Deficiency of G1 regulators P53, P21(Cip1 )and/or pRb decreases hepatocyte sensitivity to TGFβ cell cycle arrest

BACKGROUND: TGFβ is critical to control hepatocyte proliferation by inducing G1-growth arrest through multiple pathways leading to inhibition of E2F transcription activity. The retinoblastoma protein pRb is a key controller of E2F activity and G1/S transition which can be inhibited in viral hepatiti...

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Detalles Bibliográficos
Autores principales: Sheahan, Sharon, Bellamy, Christopher O, Dunbar, Donald R, Harrison, David J, Prost, Sandrine
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2206047/
https://www.ncbi.nlm.nih.gov/pubmed/18021445
http://dx.doi.org/10.1186/1471-2407-7-215

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2206047/
https://www.ncbi.nlm.nih.gov/pubmed/18021445
http://dx.doi.org/10.1186/1471-2407-7-215

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