Interleukin-1 receptor antagonist delivered directly and by gene therapy inhibits matrix degradation in the intact degenerate human intervertebral disc: an in situ zymographic and gene therapy study

Data implicate IL-1 in the altered matrix biology that characterizes human intervertebral disc (IVD) degeneration. In the current study we investigated the enzymic mechanism by which IL-1 induces matrix degradation in degeneration of the human IVD, and whether the IL-1 inhibitor IL-1 receptor antago...

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Detalles Bibliográficos
Autores principales: Le Maitre, Christine L, Hoyland, Judith A, Freemont, Anthony J
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2206387/
https://www.ncbi.nlm.nih.gov/pubmed/17760968
http://dx.doi.org/10.1186/ar2282

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2206387/
https://www.ncbi.nlm.nih.gov/pubmed/17760968
http://dx.doi.org/10.1186/ar2282

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