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Lineage Diversion of T Cell Receptor Transgenic Thymocytes Revealed by Lineage Fate Mapping

BACKGROUND: The binding of the T cell receptor (TCR) to major histocompatibility complex (MHC) molecules in the thymus determines fates of TCRαβ lymphocytes that subsequently home to secondary lymphoid tissue. TCR transgenic models have been used to study thymic selection and lineage commitment. Mos...

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Detalles Bibliográficos
Autores principales: Egawa, Takeshi, Kreslavsky, Taras, Littman, Dan R., von Boehmer, Harald
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211402/
https://www.ncbi.nlm.nih.gov/pubmed/18231598
http://dx.doi.org/10.1371/journal.pone.0001512