A Role for Mac-1 (CDIIb/CD18) in Immune Complex–stimulated Neutrophil Function In Vivo: Mac-1 Deficiency Abrogates Sustained Fcγ Receptor–dependent Neutrophil Adhesion and Complement-dependent Proteinuria in Acute Glomerulonephritis

Mac-1 (α(m)β(2)), a leukocyte adhesion receptor, has been shown in vitro to functionally interact with Fcγ receptors to facilitate immune complex (IC)–stimulated polymorphonuclear neutrophil (PMN) functions. To investigate the relevance of Mac-1–FcγR interactions in IC-mediated injury in vivo, we in...

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Detalles Bibliográficos
Autores principales: Tang, Tao, Rosenkranz, Alexander, Assmann, Karel J.M., Goodman, Michael J., Gutierrez-Ramos, Jose-Carlos, Carroll, Michael C., Cotran, Ramzi S., Mayadas, Tanya N.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1997
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211718/
https://www.ncbi.nlm.nih.gov/pubmed/9382884

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211718/
https://www.ncbi.nlm.nih.gov/pubmed/9382884

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