DNA Polymerase η Is Involved in Hypermutation Occurring during Immunoglobulin Class Switch Recombination

Base substitutions, deletions, and duplications are observed at the immunoglobulin locus in DNA sequences involved in class switch recombination (CSR). These mutations are dependent upon activation-induced cytidine deaminase (AID) and present all the characteristics of the ones observed during V gen...

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Detalles Bibliográficos
Autores principales: Faili, Ahmad, Aoufouchi, Said, Weller, Sandra, Vuillier, Françoise, Stary, Anne, Sarasin, Alain, Reynaud, Claude-Agnès, Weill, Jean-Claude
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2004
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211761/
https://www.ncbi.nlm.nih.gov/pubmed/14734526
http://dx.doi.org/10.1084/jem.20031831

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211761/
https://www.ncbi.nlm.nih.gov/pubmed/14734526
http://dx.doi.org/10.1084/jem.20031831

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