Breaking Tolerance to Double Stranded DNA, Nucleosome, and Other Nuclear Antigens Is Not Required for the Pathogenesis of Lupus Glomerulonephritis

In lupus-prone NZM2328 mice, a locus Cgnz1 on chromosome 1 was linked to chronic glomerulonephritis, severe proteinuria, and early mortality in females. A locus Adnz1 on chromosome 4 was linked to antinuclear antibody (ANA) and anti–double stranded DNA (dsDNA) antibody (Ab) production. In this inves...

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Detalles Bibliográficos
Autores principales: Waters, Samuel T., McDuffie, Marcia, Bagavant, Harini, Deshmukh, Umesh S., Gaskin, Felicia, Jiang, Chao, Tung, Kenneth S.K., Fu, Shu Man
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2004
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211766/
https://www.ncbi.nlm.nih.gov/pubmed/14718514
http://dx.doi.org/10.1084/jem.20031519

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211766/
https://www.ncbi.nlm.nih.gov/pubmed/14718514
http://dx.doi.org/10.1084/jem.20031519

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