Ubiquitin-dependent Degradation of p73 Is Inhibited by PML

p73 has been identified recently as a structural and functional homologue of the tumor suppressor p53. Here, we report that p73 stability is directly regulated by the ubiquitin–proteasome pathway. Furthermore, we show that the promyelocytic leukemia (PML) protein modulates p73 half-life by inhibitin...

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Detalles Bibliográficos
Autores principales: Bernassola, Francesca, Salomoni, Paolo, Oberst, Andrew, Di Como, Charles J., Pagano, Michele, Melino, Gerry, Pandolfi, Pier Paolo
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2004
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211783/
https://www.ncbi.nlm.nih.gov/pubmed/15184504
http://dx.doi.org/10.1084/jem.20031943

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211783/
https://www.ncbi.nlm.nih.gov/pubmed/15184504
http://dx.doi.org/10.1084/jem.20031943

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