Survivin Loss in Thymocytes Triggers p53-mediated Growth Arrest and p53-independent Cell Death

Because survivin-null embryos die at an early embryonic stage, the role of survivin in thymocyte development is unknown. We have investigated the role by deleting the survivin gene only in the T lineage and show here that loss of survivin blocks the transition from CD4(−) CD8(−) double negative (DN)...

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Detalles Bibliográficos
Autores principales: Okada, Hitoshi, Bakal, Chris, Shahinian, Arda, Elia, Andrew, Wakeham, Andrew, Suh, Woong-Kyung, Duncan, Gordon S., Ciofani, Maria, Rottapel, Robert, Zúñiga-Pflücker, Juan Carlos, Mak, Tak W.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2004
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211792/
https://www.ncbi.nlm.nih.gov/pubmed/14757745
http://dx.doi.org/10.1084/jem.20032092

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211792/
https://www.ncbi.nlm.nih.gov/pubmed/14757745
http://dx.doi.org/10.1084/jem.20032092

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