Unc119, a Novel Activator of Lck/Fyn, Is Essential for T Cell Activation

The first step in T cell receptor for antigen (TCR) signaling is the activation of the receptor-bound Src kinases, Lck and Fyn. The exact mechanism of this process is unknown. Here, we report that the novel Src homology (SH) 3/SH2 ligand–Uncoordinated 119 (Unc119) associates with CD3 and CD4, and ac...

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Detalles Bibliográficos
Autores principales: Gorska, Magdalena M., Stafford, Susan J., Cen, Osman, Sur, Sanjiv, Alam, Rafeul
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2004
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211793/
https://www.ncbi.nlm.nih.gov/pubmed/14757743
http://dx.doi.org/10.1084/jem.20030589

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211793/
https://www.ncbi.nlm.nih.gov/pubmed/14757743
http://dx.doi.org/10.1084/jem.20030589

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