Asymmetric Division and Lineage Commitment at the Level of Hematopoietic Stem Cells: Inference from Differentiation in Daughter Cell and Granddaughter Cell Pairs

How hematopoietic stem cells (HSCs) commit to a particular lineage is unclear. A high degree of HSC purification enabled us to address this issue at the clonal level. Single-cell transplantation studies revealed that 40% of the CD34(−/low), c-Kit(+), Sca-1(+), and lineage marker(−) (CD34(−)KSL) cell...

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Detalles Bibliográficos
Autores principales: Takano, Hina, Ema, Hideo, Sudo, Kazuhiro, Nakauchi, Hiromitsu
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2004
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211802/
https://www.ncbi.nlm.nih.gov/pubmed/14744992
http://dx.doi.org/10.1084/jem.20030929

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211802/
https://www.ncbi.nlm.nih.gov/pubmed/14744992
http://dx.doi.org/10.1084/jem.20030929

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