Deficiency of the Cyclin Kinase Inhibitor p21(WAF-1/CIP-1) Promotes Apoptosis of Activated/Memory T Cells and Inhibits Spontaneous Systemic Autoimmunity

A characteristic feature of systemic lupus erythematosus is the accumulation of activated/memory T and B cells. These G(0)/G(1)-arrested cells express high levels of cyclin-dependent kinase inhibitors such as p21, are resistant to proliferation and apoptosis, and produce large amounts of proinflamma...

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Detalles Bibliográficos
Autores principales: Lawson, Brian R., Baccala, Roberto, Song, Jianxun, Croft, Michael, Kono, Dwight H., Theofilopoulos, Argyrios N.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2004
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211831/
https://www.ncbi.nlm.nih.gov/pubmed/14970181
http://dx.doi.org/10.1084/jem.20031685

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211831/
https://www.ncbi.nlm.nih.gov/pubmed/14970181
http://dx.doi.org/10.1084/jem.20031685

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