Absence of DNA Polymerase η Reveals Targeting of C Mutations on the Nontranscribed Strand in Immunoglobulin Switch Regions

Activation-induced cytosine deaminase preferentially deaminates C in DNA on the nontranscribed strand in vitro, which theoretically should produce a large increase in mutations of C during hypermutation of immunoglobulin genes. However, a bias for C mutations has not been observed among the mutation...

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Detalles Bibliográficos
Autores principales: Zeng, Xianmin, Negrete, George A., Kasmer, Cynthia, Yang, William W., Gearhart, Patricia J.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2004
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211872/
https://www.ncbi.nlm.nih.gov/pubmed/15051760
http://dx.doi.org/10.1084/jem.20032022

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211872/
https://www.ncbi.nlm.nih.gov/pubmed/15051760
http://dx.doi.org/10.1084/jem.20032022

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