Arylamine N-Acetyltransferase Is Required for Synthesis of Mycolic Acids and Complex Lipids in Mycobacterium bovis BCG and Represents a Novel Drug Target

Mycolic acids represent a major component of the unique cell wall of mycobacteria. Mycolic acid biosynthesis is inhibited by isoniazid, a key frontline antitubercular drug that is inactivated by mycobacterial and human arylamine N-acetyltransferase (NAT). We show that an in-frame deletion of Mycobac...

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Detalles Bibliográficos
Autores principales: Bhakta, Sanjib, Besra, Gurdyal S., Upton, Anna M., Parish, Tanya, Sholto-Douglas-Vernon, Carolyn, Gibson, Kevin J.C., Knutton, Stuart, Gordon, Siamon, daSilva, Rosangela P., Anderton, Matthew C., Sim, Edith
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2004
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211905/
https://www.ncbi.nlm.nih.gov/pubmed/15117974
http://dx.doi.org/10.1084/jem.20031956

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211905/
https://www.ncbi.nlm.nih.gov/pubmed/15117974
http://dx.doi.org/10.1084/jem.20031956

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