Somatic Hypermutation Is Limited by CRM1-dependent Nuclear Export of Activation-induced Deaminase

Somatic hypermutation (SHM) and class switch recombination (CSR) are initiated in activated B lymphocytes by activation-induced deaminase (AID). AID is thought to make lesions in DNA by deaminating cytidine residues in single-stranded DNA exposed by RNA polymerase during transcription. Although this...

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Detalles Bibliográficos
Autores principales: McBride, Kevin M., Barreto, Vasco, Ramiro, Almudena R., Stavropoulos, Pete, Nussenzweig, Michel C.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2004
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211910/
https://www.ncbi.nlm.nih.gov/pubmed/15117971
http://dx.doi.org/10.1084/jem.20040373

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211910/
https://www.ncbi.nlm.nih.gov/pubmed/15117971
http://dx.doi.org/10.1084/jem.20040373

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