Bone Marrow Microenvironmental Changes Underlie Reduced RAG-mediated Recombination and B Cell Generation in Aged Mice

During aging, adaptive immunity is severely compromised, due in part to decreased production of B lymphocytes and loss of immunoglobulin (Ig) diversity. However, the molecular mechanisms that underlie age-associated diminished B cell production remain unclear. Using in vivo labeling, we find that th...

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Detalles Bibliográficos
Autores principales: Labrie, Joseph E., Sah, Alex P., Allman, David M., Cancro, Michael P., Gerstein, Rachel M.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2004
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211932/
https://www.ncbi.nlm.nih.gov/pubmed/15314072
http://dx.doi.org/10.1084/jem.20040845

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211932/
https://www.ncbi.nlm.nih.gov/pubmed/15314072
http://dx.doi.org/10.1084/jem.20040845

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