Cargando…

Tumor Necrosis Factor (TNF) Receptor Shedding Controls Thresholds of Innate Immune Activation That Balance Opposing TNF Functions in Infectious and Inflammatory Diseases

Tumor necrosis factor (TNF) is a potent cytokine exerting critical functions in the activation and regulation of immune and inflammatory responses. Due to its pleiotropic activities, the amplitude and duration of TNF function must be tightly regulated. One of the mechanisms that may have evolved to...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xanthoulea, Sofia, Pasparakis, Manolis, Kousteni, Stavroula, Brakebusch, Cord, Wallach, David, Bauer, Jan, Lassmann, Hans, Kollias, George
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2004
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211976/ https://www.ncbi.nlm.nih.gov/pubmed/15289505 http://dx.doi.org/10.1084/jem.20040435

Ejemplares similares

A Critical Role of the p75 Tumor Necrosis Factor Receptor (p75TNF-R) in Organ Inflammation Independent of TNF, Lymphotoxin α, or the p55TNF-R
por: Douni, Eleni, et al.
Publicado: (1998)

Uncoupling the Proinflammatory from the Immunosuppressive Properties of Tumor Necrosis Factor (Tnf) at the P55 TNF Receptor Level: Implications for Pathogenesis and Therapy of Autoimmune Demyelination
por: Kassiotis, George, et al.
Publicado: (2001)

Complementation of Lymphotoxin α Knockout Mice with Tumor Necrosis Factor–expressing Transgenes Rectifies Defective Splenic Structure and Function
por: Alexopoulou, Lena, et al.
Publicado: (1998)

C-tag TNF: a reporter system to study TNF shedding
por: Pinci, Francesca, et al.
Publicado: (2021)

Endothelial and Macrophage-Specific Deficiency of P38α MAPK Does Not Affect the Pathogenesis of Atherosclerosis in ApoE(−/−) Mice
por: Kardakaris, Rozina, et al.
Publicado: (2011)

Sulforaphane has opposing effects on TNF-alpha stimulated and unstimulated synoviocytes
por: Fragoulis, Athanassios, et al.
Publicado: (2012)

A metalloprotease inhibitor blocks shedding of the 80-kD TNF receptor and TNF processing in T lymphocytes
Publicado: (1995)

Membrane-Bound TNF Induces Protective Immune Responses to M. bovis BCG Infection: Regulation of memTNF and TNF Receptors Comparing Two memTNF Molecules
por: Olleros, Maria L., et al.
Publicado: (2012)

Dual role of the p75 tumor necrosis factor (TNF) receptor in TNF cytotoxicity
Publicado: (1994)

Attenuation of inflammatory polyarthritis in TNF transgenic mice by diacerein: comparative analysis with dexamethasone, methotrexate and anti-TNF protocols
por: Douni, Eleni, et al.
Publicado: (2004)

Tumor necrosis factor-α, TNF receptor, and soluble TNF receptor responses to aerobic exercise in the heat
por: Arroyo, Eliott, et al.
Publicado: (2020)

Overexpression of TNF causes bilateral sacroiliitis
por: Redlich, K, et al.
Publicado: (2004)

The antitumor function of tumor necrosis factor (TNF) II. Analysis of the role of endogenous TNF in endotoxin-induced hemorrhagic necrosis and regression of an established sarcoma
Publicado: (1988)

Antiviral Activity of Tumor Necrosis Factor (TNF) Is Mediated via p55 and p75 TNF Receptors
por: Ruby, Janet, et al.
Publicado: (1997)

The Role of Tumor Necrosis Factor Alpha (TNF-α) in Autoimmune Disease and Current TNF-α Inhibitors in Therapeutics
por: Jang, Dan-in, et al.
Publicado: (2021)

IKKβ in intestinal mesenchymal cells promotes initiation of colitis-associated cancer
por: Koliaraki, Vasiliki, et al.
Publicado: (2015)

Elevated cAMP opposes (TNF-α)-induced loss in the barrier integrity of corneal endothelium
por: Shivanna, Mahesh, et al.
Publicado: (2010)

Downregulation of tumor necrosis factor (TNF) sensitivity via modulation of TNF binding capacity by protein kinase C activators
Publicado: (1987)

Tumor Necrosis Factor (TNF) and Chemokines in Colitis-Associated Cancer
por: Mukaida, Naofumi, et al.
Publicado: (2011)

Extracellular sphingomyelinase activity impairs TNF-α-induced endothelial cell death via ADAM17 activation and TNF receptor 1 shedding
por: Sommer, Anselm, et al.
Publicado: (2017)

Tumor necrosis factor alpha (TNF-alpha)-induced cell adhesion to human endothelial cells is under dominant control of one TNF receptor type, TNF-R55
Publicado: (1993)

In Silico Discovery of Plant-Origin Natural Product Inhibitors of Tumor Necrosis Factor (TNF) and Receptor Activator of NF-κB Ligand (RANKL)
por: Melagraki, Georgia, et al.
Publicado: (2018)

Induced Expression of Trimerized Intracellular Domains of the Human Tumor Necrosis Factor (TNF) p55 Receptor Elicits TNF Effects
por: Vandevoorde, Veronique, et al.
Publicado: (1997)

Identification of a 60-kD tumor necrosis factor (TNF) receptor as the major signal transducing component in TNF responses
Publicado: (1990)

Ceramide Kinase Regulates the Production of Tumor Necrosis Factor α (TNFα) via Inhibition of TNFα-converting Enzyme
por: Lamour, Nadia F., et al.
Publicado: (2011)

Tumor Necrosis Factor (TNF) Receptor Expression Determines Keratinocyte Fate upon Stimulation with TNF-Like Weak Inducer of Apoptosis
por: Wang, Xuening, et al.
Publicado: (2019)

Osteoclasts are essential for TNF-mediated joint destruction
por: Redlich, KR, et al.
Publicado: (2002)

Associations of Tumor Necrosis Factor-Alpha Gene Polymorphisms (TNF)-α TNF-863A/C (rs1800630), TNF-308A/G (rs1800629), TNF-238A/G (rs361525), and TNF-Alpha Serum Concentration with Age-Related Macular Degeneration
por: Zazeckyte, Guoda, et al.
Publicado: (2022)

The p55TNFR-IKK2-Ripk3 axis orchestrates arthritis by regulating death and inflammatory pathways in synovial fibroblasts
por: Armaka, Marietta, et al.
Publicado: (2018)

MK2 Phosphorylates RIPK1 to Prevent TNF-Induced Cell Death
por: Jaco, Isabel, et al.
Publicado: (2017)

Isolated and combined inhibition of TNF-, IL-1 and RANKL-pathways in TNF-induced arthritis: effects on synovial inflammation, bone erosion and cartilage destruction
por: Zwerina, J, et al.
Publicado: (2003)

Repair of local bone erosions and reversal of systemic bone loss upon therapy with anti-TNF in combination with OPG or PTH in TNF-mediated arthritis
por: Redlich, K, et al.
Publicado: (2004)

A20 protects cells from TNF-induced apoptosis through linear ubiquitin-dependent and -independent mechanisms
por: Priem, Dario, et al.
Publicado: (2019)

A tumor necrosis factor (TNF) receptor-IgG heavy chain chimeric protein as a bivalent antagonist of TNF activity
Publicado: (1991)

A human tumor necrosis factor (TNF) alpha mutant that binds exclusively to the p55 TNF receptor produces toxicity in the baboon
Publicado: (1994)

Primate TNF Promoters Reveal Markers of Phylogeny and Evolution of Innate Immunity
por: Baena, Andres, et al.
Publicado: (2007)

Combination of subtherapeutic anti-TNF dose with dasatinib restores clinical and molecular arthritogenic profiles better than standard anti-TNF treatment
por: Ntari, Lydia, et al.
Publicado: (2021)

Innate Sensing through Mesenchymal TLR4/MyD88 Signals Promotes Spontaneous Intestinal Tumorigenesis
por: Koliaraki, Vasiliki, et al.
Publicado: (2019)

TNF and anti-TNF agents in Behçet's disease
por: Calamia, KT
Publicado: (2003)

Soluble TNF Mediates the Transition from Pulmonary Inflammation to Fibrosis
por: Oikonomou, Nikos, et al.
Publicado: (2006)

Cannot write session to /tmp/vufind_sessions/sess_k568jpoiaa5m5fmkpn20sn5sqf