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Anthrolysin O and Other Gram-positive Cytolysins Are Toll-like Receptor 4 Agonists

Exposure of bone marrow–derived macrophages (BMDMs) to low concentrations of Bacillus anthracis lethal toxin (LT), whose catalytic subunit is lethal factor (LF), results in induction of a robust apoptotic response dependent on activation of Toll-like receptor (TLR)4. A similar TLR4-dependent apoptot...

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Detalles Bibliográficos
Autores principales:	Park, Jin Mo, Ng, Vincent H., Maeda, Shin, Rest, Richard F., Karin, Michael
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2004
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211988/ https://www.ncbi.nlm.nih.gov/pubmed/15611291 http://dx.doi.org/10.1084/jem.20041215

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