Combined loss of proapoptotic genes Bak or Bax with Bim synergizes to cause defects in hematopoiesis and in thymocyte apoptosis

The proapoptotic members of the Bcl-2 family can be subdivided into members that contain several Bcl-2 homology (BH) domains and those that contain only the BH3 domain. Although it is known that BH3-only proteins and the multi-BH domain proteins, Bak and Bax, are essential for programmed cell death,...

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Detalles Bibliográficos
Autores principales: Hutcheson, Jack, Scatizzi, John C., Bickel, Emily, Brown, Nathaniel J., Bouillet, Philippe, Strasser, Andreas, Perlman, Harris
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2005
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212027/
https://www.ncbi.nlm.nih.gov/pubmed/15967824
http://dx.doi.org/10.1084/jem.20041484

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212027/
https://www.ncbi.nlm.nih.gov/pubmed/15967824
http://dx.doi.org/10.1084/jem.20041484

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