B cells from hyper-IgM patients carrying UNG mutations lack ability to remove uracil from ssDNA and have elevated genomic uracil

The generation of high-affinity antibodies requires somatic hypermutation (SHM) and class switch recombination (CSR) at the immunoglobulin (Ig) locus. Both processes are triggered by activation-induced cytidine deaminase (AID) and require UNG-encoded uracil-DNA glycosylase. AID has been suggested to...

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Detalles Bibliográficos
Autores principales: Kavli, Bodil, Andersen, Sonja, Otterlei, Marit, Liabakk, Nina B., Imai, Kohsuke, Fischer, Alain, Durandy, Anne, Krokan, Hans E., Slupphaug, Geir
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2005
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212036/
https://www.ncbi.nlm.nih.gov/pubmed/15967827
http://dx.doi.org/10.1084/jem.20050042

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212036/
https://www.ncbi.nlm.nih.gov/pubmed/15967827
http://dx.doi.org/10.1084/jem.20050042

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