A Novel Sialic Acid Binding Site on Factor H Mediates Serum Resistance of Sialylated Neisseria gonorrhoeae

Factor H (fH), a key alternative complement pathway regulator, is a cofactor for factor I–mediated cleavage of C3b. fH consists of 20 short consensus repeat (SCR) domains. Sialic acid binding domains have previously been localized to fH SCRs 6–10 and 13. To examine fH binding on a sialylated microbi...

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Detalles Bibliográficos
Autores principales: Ram, Sanjay, Sharma, Ajay K., Simpson, Scott D., Gulati, Sunita, McQuillen, Daniel P., Pangburn, Michael K., Rice, Peter A.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1998
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212180/
https://www.ncbi.nlm.nih.gov/pubmed/9480984

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212180/
https://www.ncbi.nlm.nih.gov/pubmed/9480984

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