Conversion of Membrane-bound Fas(CD95) Ligand to Its Soluble Form Is Associated with Downregulation of Its Proapoptotic Activity and Loss of Liver Toxicity

Human Fas ligand (L) (CD95L) and tumor necrosis factor (TNF)-α undergo metalloproteinase-mediated proteolytic processing in their extracellular domains resulting in the release of soluble trimeric ligands (soluble [s]FasL, sTNF-α) which, in the case of sFasL, is thought to be implicated in diseases...

Descripción completa

Detalles Bibliográficos
Autores principales: Schneider, Pascal, Holler, Nils, Bodmer, Jean-Luc, Hahne, Michael, Frei, Karl, Fontana, Adriano, Tschopp, Jürg
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1998
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212219/
https://www.ncbi.nlm.nih.gov/pubmed/9547332

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212219/
https://www.ncbi.nlm.nih.gov/pubmed/9547332

Ejemplares similares