Control of Lytic Function by Mitogen-activated Protein Kinase/Extracellular Regulatory Kinase 2 (ERK2) in a Human Natural Killer Cell Line: Identification of Perforin and Granzyme B Mobilization by Functional ERK2

The signal pathways that control effector function in human natural killer (NK) cells are little known. In this study, we have identified the critical role of the mitogen-activated protein kinase (MAPK) pathway in NK lysis of tumor cells, and this pathway may involve the mobilization of granule comp...

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Detalles Bibliográficos
Autores principales: Wei, Sheng, Gamero, Ana M., Liu, Jin Hong, Daulton, Angela A., Valkov, Nichola I., Trapani, Joseph A., Larner, Andrew C., Weber, Michael J., Djeu, Julie Y.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1998
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212310/
https://www.ncbi.nlm.nih.gov/pubmed/9607917

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212310/
https://www.ncbi.nlm.nih.gov/pubmed/9607917

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