Increased Hypermutation at G and C Nucleotides in Immunoglobulin Variable Genes from Mice Deficient in the MSH2 Mismatch Repair Protein

Rearranged immunoglobulin variable genes are extensively mutated after stimulation of B lymphocytes by antigen. Mutations are likely generated by an error-prone DNA polymerase, and the mismatch repair pathway may process the mispairs. To examine the role of the MSH2 mismatch repair protein in hyperm...

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Detalles Bibliográficos
Autores principales: Phung, Quy H., Winter, David B., Cranston, Aaron, Tarone, Robert E., Bohr, Vilhelm A., Fishel, Richard, Gearhart, Patricia J.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1998
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212314/
https://www.ncbi.nlm.nih.gov/pubmed/9607916

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212314/
https://www.ncbi.nlm.nih.gov/pubmed/9607916

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