Cargando…

Increased Hypermutation at G and C Nucleotides in Immunoglobulin Variable Genes from Mice Deficient in the MSH2 Mismatch Repair Protein

Rearranged immunoglobulin variable genes are extensively mutated after stimulation of B lymphocytes by antigen. Mutations are likely generated by an error-prone DNA polymerase, and the mismatch repair pathway may process the mispairs. To examine the role of the MSH2 mismatch repair protein in hyperm...

Descripción completa

Detalles Bibliográficos
Autores principales:	Phung, Quy H., Winter, David B., Cranston, Aaron, Tarone, Robert E., Bohr, Vilhelm A., Fishel, Richard, Gearhart, Patricia J.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 1998
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212314/ https://www.ncbi.nlm.nih.gov/pubmed/9607916

Ejemplares similares

A Role for Msh6 But Not Msh3 in Somatic Hypermutation and Class Switch Recombination
por: Martomo, Stella A., et al.
Publicado: (2004)

Dependence of nucleotide substitutions on Ung2, Msh2, and PCNA-Ub during somatic hypermutation
por: Krijger, Peter H.L., et al.
Publicado: (2009)

Complex MSH2 and MSH6 mutations in hypermutated microsatellite unstable advanced prostate cancer
por: Pritchard, Colin C., et al.
Publicado: (2014)

The Role of DNA Repair in Somatic Hypermutation of Immunoglobulin Genes
por: Kim, Nayun, et al.
Publicado: (1998)

Cadmium inhibits mismatch repair by blocking the ATPase activity of the MSH2–MSH6 complex
por: Banerjee, Sreeparna, et al.
Publicado: (2005)

Cadmium inhibits mismatch repair by blocking the ATPase activity of the MSH2–MSH6 complex
por: Banerjee, Sreeparna, et al.
Publicado: (2005)

Mlh1 interacts with both Msh2 and Msh6 for recruitment during mismatch repair
por: DuPrie, Matthew L., et al.
Publicado: (2022)

Severe Attenuation of the B Cell Immune Response in Msh2-deficient Mice
por: Vora, Kalpit A., et al.
Publicado: (1999)

Prerecognition Diffusion Mechanism of Human DNA Mismatch Repair Proteins along DNA: Msh2-Msh3 versus Msh2-Msh6
por: Pal, Arumay, et al.
Publicado: (2020)

Immunohistochemical Loss of the DNA Mismatch Repair Proteins MSH2 and MSH6 in Malignant Fibrous Histiocytomas
por: Ericson, Kajsa, et al.
Publicado: (2004)

Somatic Hypermutation in Muts Homologue (Msh)3-, Msh6-, and Msh3/Msh6-Deficient Mice Reveals a Role for the Msh2–Msh6 Heterodimer in Modulating the Base Substitution Pattern
por: Wiesendanger, Margrit, et al.
Publicado: (2000)

Characterization and comparative sequence analysis of the DNA mismatch repair MSH2 and MSH7 genes from tomato
por: Tam, Sheh May, et al.
Publicado: (2009)

MSH2/MSH6 Complex Promotes Error-Free Repair of AID-Induced dU:G Mispairs as well as Error-Prone Hypermutation of A:T Sites
por: Roa, Sergio, et al.
Publicado: (2010)

DNA mismatch repair promotes APOBEC3-mediated diffuse hypermutation in human cancers
por: Mas-Ponte, David, et al.
Publicado: (2020)

The efficacy of DNA mismatch repair enzyme immunohistochemistry as a screening test for hypermutated gliomas
por: McCord, Matthew, et al.
Publicado: (2020)

OTUB1 stabilizes mismatch repair protein MSH2 by blocking ubiquitination
por: Wu, Qiong, et al.
Publicado: (2021)

Hypermutation of Immunoglobulin Genes in Memory B Cells of DNA Repair–deficient Mice
por: Jacobs, Heinz, et al.
Publicado: (1998)

The properties of Msh2–Msh6 ATP binding mutants suggest a signal amplification mechanism in DNA mismatch repair
por: Graham, William J., et al.
Publicado: (2018)

An Evaluation of the Immunohistochemical Expression of Mismatch Repair Proteins (MSH2, MSH6, MLH1, and PMS2) in Prostate Adenocarcinoma
por: Javeed, Saira, et al.
Publicado: (2022)

Role for Mismatch Repair Proteins Msh2, Mlh1, and Pms2 in Immunoglobulin Class Switching Shown by Sequence Analysis of Recombination Junctions
por: Schrader, Carol E., et al.
Publicado: (2002)

129-derived Strains of Mice Are Deficient in DNA Polymerase ι and Have Normal Immunoglobulin Hypermutation
por: McDonald, John P., et al.
Publicado: (2003)

Germline POLE mutation in a child with hypermutated medulloblastoma and features of constitutional mismatch repair deficiency
por: Lindsay, Holly, et al.
Publicado: (2019)

Trans-Lesion Synthesis and Mismatch Repair Pathway Crosstalk Defines Chemoresistance and Hypermutation Mechanisms in Glioblastoma
por: Cheng, Xing, et al.
Publicado: (2023)

Trans-Lesion Synthesis and Mismatch Repair Pathway Crosstalk Defines Chemoresistance and Hypermutation Mechanisms in Glioblastoma
por: Cheng, Xing, et al.
Publicado: (2023)

Immunoglobulin switch μ sequence causes RNA polymerase II accumulation and reduces dA hypermutation
por: Rajagopal, Deepa, et al.
Publicado: (2009)

Mismatch Recognition by Saccharomyces cerevisiae Msh2-Msh6: Role of Structure and Dynamics
por: Li, Yan, et al.
Publicado: (2019)

NPM-ALK mediates phosphorylation of MSH2 at tyrosine 238, creating a functional deficiency in MSH2 and the loss of mismatch repair
por: Bone, K M, et al.
Publicado: (2015)

The mismatch-repair proteins MSH2 and MSH6 interact with the imprinting control regions through the ZFP57-KAP1 complex
por: Acurzio, Basilia, et al.
Publicado: (2022)

DNA mismatch repair gene MSH6 implicated in determining age at natural menopause
por: Perry, John R.B., et al.
Publicado: (2014)

The Aspergillus fumigatus Mismatch Repair MSH2 Homolog Is Important for Virulence and Azole Resistance
por: dos Reis, Thaila Fernanda, et al.
Publicado: (2019)

A Role for PCNA Ubiquitination in Immunoglobulin Hypermutation
por: Arakawa, Hiroshi, et al.
Publicado: (2006)

B Lymphocytes of Xeroderma Pigmentosum or Cockayne Syndrome Patients with Inherited Defects in Nucleotide Excision Repair Are Fully Capable of Somatic Hypermutation of Immunoglobulin Genes
por: Kim, Nayun, et al.
Publicado: (1997)

Screening of the DNA mismatch repair genes MLH1, MSH2 and MSH6 in a Greek cohort of Lynch syndrome suspected families
por: Thodi, Georgia, et al.
Publicado: (2010)

Mismatch Repair Proteins and Microsatellite Instability in Colorectal Carcinoma (MLH1, MSH2, MSH6 and PMS2): Histopathological and Immunohistochemical Study
por: Ismael, Nour El Hoda S., et al.
Publicado: (2017)

Repertoire Sequencing of B Cells Elucidates the Role of UNG and Mismatch Repair Proteins in Somatic Hypermutation in Humans
por: IJspeert, Hanna, et al.
Publicado: (2019)

Mismatch-repair protein MSH6 is associated with Ku70 and regulates DNA double-strand break repair
por: Shahi, Ankita, et al.
Publicado: (2011)

Mismatch Repair Protein Msh2 Is Necessary for Macronuclear Stability and Micronuclear Division in Tetrahymena thermophila
por: Wang, Lin, et al.
Publicado: (2023)

Msh2 ATPase Activity Is Essential for Somatic Hypermutation at A-T Basepairs and for Efficient Class Switch Recombination
por: Martin, Alberto, et al.
Publicado: (2003)

Somatic hypermutation of an immunoglobulin mu heavy chain transgene
Publicado: (1993)

Lynch syndrome–associated ultra-hypermutated pediatric glioblastoma mimicking a constitutional mismatch repair deficiency syndrome
por: Yang, Chen, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_50ks72gaapjd3tii9q3hb8jh06