Expression of Constitutively Active Raf-1 in the Mitochondria Restores Antiapoptotic and Leukemogenic Potential of a Transformation-deficient BCR/ABL Mutant

The oncogenic BCR/ABL protein protects hematopoietic cells from apoptosis induced by growth factor deprivation, but the mechanisms are only partially understood. A BCR/ABL mutant lacking amino acids 176–426 in the BCR domain (p185ΔBCR) failed to protect interleukin 3–deprived 32Dcl3 myeloid precurso...

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Detalles Bibliográficos
Autores principales: Salomoni, Paolo, Wasik, Mariusz A., Riedel, Richard F., Reiss, Krzysztof, Choi, John K., Skorski, Tomasz, Calabretta, Bruno
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1998
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212373/
https://www.ncbi.nlm.nih.gov/pubmed/9625759

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212373/
https://www.ncbi.nlm.nih.gov/pubmed/9625759

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