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Visualization of CD4/CD8 T Cell Commitment

A system to innocuously visualize T cell lineage commitment is described. Using a “knock-in” approach, we have generated mice expressing a β-galactosidase reporter in place of CD4; expression of β-galactosidase in these animals appears to be an accurate and early indicator of CD4 gene transcription....

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Detalles Bibliográficos
Autores principales: Chan, Susan, Correia-Neves, Margarida, Dierich, Andrée, Benoist, Christophe, Mathis, Diane
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1998
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212422/
https://www.ncbi.nlm.nih.gov/pubmed/9858518