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Requirement of CD3 Complex–associated Signaling Functions for Expression of Rearranged T Cell Receptor β VDJ Genes in Early Thymic Development

During αβ thymocyte development, the clonotypic αβ–T cell receptor (TCR) is preceded by sequentially expressed immature versions of the TCR–CD3 complex: the pre-TCR, containing a clonotypic TCR-β chain and invariant pre-Tα, is expressed on pre-T cells before rearrangement of the TCR-α locus. Moreove...

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Detalles Bibliográficos
Autores principales: Würch, Andreas, Biro, Judit, Potocnik, Alexandre J., Falk, Ingrid, Mossmann, Horst, Eichmann, Klaus
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1998
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212509/
https://www.ncbi.nlm.nih.gov/pubmed/9802979